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Eye conditions
Corneal surgery

Corneal transplant

When the cornea is too distorted or clouded to be corrected any other way, transplant (keratoplasty) replaces the damaged part with a clear graft. Modern techniques often replace only a single layer of the cornea, for safer recovery.

Donor graft
healthy, clear cornea
Lamellar grafts
only one layer replaced
~12 months of follow-up
to prevent rejection
Corneal transplant: the clear central graft is held in place by fine sutures arranged in a ring around the cornea
A corneal graft in place, held by fine sutures.

Corneal transplant: the essentials in 30 seconds

  • Indicated when the cornea has permanently lost its transparency or shape (advanced keratoconus, dystrophies, scars).
  • Modern techniques often replace only the diseased layer (lamellar grafts): faster recovery.
  • As the cornea has no blood supply, rejection is less common than with other transplants — but follow-up remains essential.
  • Complete assessment at the practice and referral to the appropriate procedure.
1

What is a corneal transplant?

The cornea is the clear lens at the front of the eye. To see well, it must remain clear and regular. When a disease or injury makes it too distorted or opaque, vision falls and cannot be restored with glasses or contact lenses.

A corneal transplant, or keratoplasty, then consists of replacing the damaged part with a clear graft taken from a donor. The cornea is made of several layers: depending on which one is affected, the surgeon replaces either its full thickness or only the diseased layer — a modern, safer approach.

Anatomical cross-section of the eye: the cornea is the thin, transparent, domed membrane at the front of the eye
The cornea: the clear lens at the front of the eye, the one a transplant replaces.
2

When is a transplant offered?

A transplant is considered when vision can no longer be improved by glasses or contact lenses, or when the cornea is under threat. The main indications:

When the cornea is too distorted or too thin and contact lenses are no longer enough. One of the leading indications for a transplant.
Fuchs' dystrophy
When the deep layer of the cornea (the endothelium) no longer acts as a pump: the cornea swells and becomes cloudy.
Scars & opacities
Opacities left by an infection, injury or burn, which obstruct the line of sight.
Decompensation after surgery
More rarely, persistent corneal oedema after eye surgery, or failure of a previous graft.

The different techniques

Surgery has evolved greatly: rather than systematically replacing the whole cornea, the aim today is to change only the diseased layer and preserve the healthy layers. The surgeon chooses the technique best suited to each case.

Anterior layer
Anterior lamellar graft (DALK)
The stroma (superficial and middle part) is replaced while the patient's own healthy deep layer is kept. Indicated in particular in keratoconus: lower risk of rejection, long-lasting graft.
Deep layer
Endothelial graft (DMEK, DSAEK)
Only the endothelium is replaced, with a thin sheet held in place by an air bubble. The technique of choice for Fuchs' dystrophy: small incision, faster recovery, less frequent rejection.
Full thickness
Penetrating graft
The cornea is replaced over its full thickness and sutured. This is the oldest technique, reserved for complete damage or for failure of the other grafts.
Infographic of the three corneal transplant techniques: anterior lamellar graft (DALK), endothelial graft (DMEK, DSAEK) and full-thickness graft
The three main transplant techniques, depending on the layer of cornea to be replaced.
3

How is the transplant carried out?

A transplant requires some organisation, because it depends on the availability of a graft. The main stages:

1 · Registration
The patient is placed on a waiting list with a cornea bank. The wait ranges from a few weeks to a few months.
2 · Pre-operative assessment
A complete assessment and an anaesthetic consultation are done in advance, so that surgery can take place quickly as soon as a graft is available.
3 · The operation
Under local or general anaesthetic, it lasts about 1 hour. The graft is put in place and then held by fine sutures or an air bubble depending on the technique.
4 · Immediate aftercare
An overnight hospital stay is often necessary. Treatment with eye drops (antibiotic, then corticosteroid) is prescribed at tapering doses over several months.

Follow-up & the risk of rejection

Corneal transplantation is a well-established procedure with generally good results. Vision returns gradually: the cornea takes several weeks to become clear again, and final adjustment (suture removal, correction) may take several months. Regular follow-up, especially in the first year, is essential.

Eye drops
Local treatment
Follow-up relies on corticosteroid eye drops at tapering doses over several months — the main protection against rejection — supplemented by artificial tears.
Longevity
A long-lasting graft
A graft can remain clear for many years. Modern lamellar techniques reduce the risk of rejection and extend the life of the graft.
Recognising rejection: an emergency

A red, painful, watering eye, reduced vision or sensitivity to light should prompt urgent consultation. Caught in time, early rejection is most often treated by stepping up corticosteroid eye drops. This is why it is so important never to space out check-ups or stop treatment without medical advice.

Corneal transplant in Noisy-le-Grand

At the Grand Paris Ophtalmologie practice, Drs Chetrit and Srour determine the indication for a corneal transplant, carry out the pre-operative assessment and provide post-operative follow-up on site, in liaison with a surgical centre, for patients from Noisy-le-Grand and east Paris (93, 94, 77): Bry-sur-Marne, Villiers-sur-Marne, Champs-sur-Marne, Chelles, Torcy and Marne-la-Vallée, as well as Le Perreux-sur-Marne, Nogent-sur-Marne, Fontenay-sous-Bois, Vincennes, Saint-Maur-des-Fossés, Créteil, Montreuil and Rosny-sous-Bois. Follow-up is provided by Dr Yaïr Chetrit or Dr Mayer Srour.

Content written and reviewed by Dr Mayer Srour, ophthalmic surgeon in Noisy-le-Grand (Grand Paris Ophtalmologie). Sources: Société Française d'Ophtalmologie (SFO), Haute Autorité de Santé (HAS), Ameli (French national health insurance website). Last updated: September 2026.
Frequently asked questions

Corneal transplant: your questions

Answers from Dr Yaïr Chetrit and Dr Mayer Srour, ophthalmologists in Noisy-le-Grand.

Is a living donor needed?

No. The graft comes from a deceased donor, via a cornea bank. Retrieval, storage and allocation are strictly regulated to ensure the safety and quality of the graft.

How long does it take to recover vision?

Recovery is gradual. The cornea takes several weeks to become clear again, and final adjustment (suture removal, correction) may take several months, especially after a penetrating graft.

Is a corneal transplant painful?

The operation is done under anaesthetic (local or general), without pain. In the following days, mild discomfort or a gritty sensation is possible, relieved by eye drops.

What are the signs of rejection?

A red, painful, watering eye, reduced vision or sensitivity to light. They require urgent consultation: caught in time, rejection is most often treated by stepping up eye drops.

Can both eyes be grafted at the same time?

No: when both eyes need a graft, the second is operated on some time after the first (generally after about a year), once the first graft has stabilised.

Does a graft last a lifetime?

Often for many years. Modern lamellar techniques extend the life of the graft; in case of wear or rejection, a new transplant remains possible.

Related reading

Condition
Keratoconus
One of the leading indications for a corneal transplant.
Examination
Corneal topography
Maps the cornea before and after the transplant.
Speciality
Contact lenses
Fitting rigid lenses, before considering a transplant.

Has a corneal transplant been mentioned to you?

Indication, pre-operative assessment and follow-up at the Noisy-le-Grand practice, with Drs Chetrit and Srour.

Book an appointment on Doctolib 01 85 10 57 00